Chronic refers to adverse effects that occur following long-term or repeated exposure to a chemical substance.
In chemical hazard and risk assessment, chronic effects are evaluated to determine the potential long-term impacts of a substance on human health and the environment.
Under the KKDIK Regulation, chronic hazards are an important consideration when assessing substances with persistent, bioaccumulative, and toxic (PBT) or very persistent and very bioaccumulative (vPvB) properties, as these substances may require additional risk management measures and regulatory controls.