Antioxidant/Electrophile Response Element is known as a DNA sequence that plays a role in the activation of genes that regulate stress response and detoxification processes in cells.
ARE regulates genes that are activated when exposed to oxidative stress or electrophilic substances, and these genes activate cellular defence mechanisms. Within the scope of KKDIK, this mechanism is especially important in the assessment of the toxicological effects of chemical substances. The potential of a substance to activate ARE provides information about the oxidative stress and potential harmful effects it can create on cells. Therefore, it is an important biochemical pathway that is taken into account in determining the safe use of the chemical.